OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection
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چکیده
منابع مشابه
Experimental Borrelia burgdorferi infection of outbred mice.
Infectivity of Borrelia burgdorferi strain 297 in normal outbred ddY mice was examined. Strain 297 was inoculated intraperitoneally in 3-week-old outbred ddY mice. B. burgdorferi was routinely cultured from the heart and urinary bladder 5 to 84 days postinoculation. The combined isolation rate from both heart and urinary bladder was significantly higher than the rate from spleen, kidney, liver,...
متن کاملMyositis during Borrelia burgdorferi infection (Lyme disease).
During the second stage of an illness caused by Borrelia burgdorferi, a young woman developed a myopathic syndrome characterised by severe muscular pains, incapacitating weakness of the proximal limb and the neck, as well as the bulbar muscles and elevated serum CK levels. Muscle biopsy revealed a non-inflammatory necrotising myopathy. B. burgdorferi infection was confirmed by a considerable ri...
متن کاملHost-adapted Borrelia burgdorferi in mice expresses OspA during inflammation.
Antibody responses to outer surface protein A (OspA) of Borrelia burgdorferi may occur during periods of arthritis late in the clinical course of untreated Lyme disease. These antibody responses are paradoxical, given the conclusive evidence demonstrating that B. burgdorferi transmitted to the mammalian host expresses little or no OspA. The parallel occurrence of OspA antibodies and arthritic e...
متن کاملLate cardiac manifestation of infection with Borrelia burgdorferi (Lyme disease).
1 Lawrence JS. Disc degeneration: its frequency and relationship to symptoms. Ann Rheum Dis 1969;28:121-38. 2 Orwoll ES, Oviatt SK, Mann T. The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men. J Clin EndocrinolMetab 1990;70:1202-7. 3 Reid IR, Evans MC, Ames R, Wattie DJ. The influence of osteophvtes and aortic calcification on spinal mineral de...
متن کاملospa sequence comparison and protection against borrelia burgdorferi infection in gerbils by recombinant ospa protein
lyme borreliosis is a tick-born disease caused by the spirochete borrelia burgdorferi. the aim of this research was molecular typing of different strains of b. burgdorferi and protective efficacy of outer surface protein in animal model. seven strains of b. burgdorferi isolated from skin and csf of lyme disease patients were compared using pcr- rflp as well as dna and amino acid sequences. the ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1993
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.61.6.2553-2557.1993